Production and Characterization of Bilayer Tissue Scaffolds Prepared with Different Alginate-Salts and Fibroin

The presented study aimed to design and characterize bilayer Alginate/Fibroin scaffolds provide faster higher quality treatment of skin tissue losses with engineering approach. In this context, it was tried form the dermis epidermis layers alginate salts (sodium calcium) fibroin a biomimetic approach, determine most suitable salt-fibroin composite scaffold by trying different production methods. optimum determined macroscopic measurement dimensional analysis produced four methods their chemical structures were controlled FTIR. Among scaffolds, calcium alginate/fibroin (CaAlg/Fb) have morphological structure. With further characterization, pore distribution size examined SEM that surface diameters vary from 30 µm 300 which are for cell settlement. thermal stability structure gravimetry, degradation rate calculated thermograms. According TG analysis, decomposition CaAlg/Fb occurs much temperature than homo-biopolymeric (CaAlg Fb) structures. As result, found capable forming full-thickness dermal and/or also osteochondral wound dressings both morphologically structurally. It is recommended perform ability performing advanced biological analyzes.